MovDisordV3, Main, Exploration, bibRecord, 003A26

Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia

Identifieur interne : 003A26 ( Main/Exploration ); précédent : 003A25; suivant : 003A27

Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia

Auteurs : Carme Junqué [Espagne] ; Blanca Ramírez-Ruiz [Espagne] ; Eduardo Tolosa [Espagne] ; Christopher Summerfield [Espagne] ; María-José Martí [Espagne] ; Pau Pastor [Espagne] ; Beatriz G Mez-Ans N [Espagne] ; José Ma. Mercader [Espagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2005-05.

RBID : ISTEX:511C6B90D55170230E261E0579B6A7EF3BD9D6F5

Descripteurs français

Pascal (Inist)
- Amygdale, Démence, Hippocampe, Imagerie RMN, Parkinson maladie, Système nerveux pathologie.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Amygdala, Amygdala (pathology), Dementia, Dementia (complications), Dementia (diagnosis), Diagnostic and Statistical Manual of Mental Disorders, Female, Hippocampus, Hippocampus (pathology), Humans, MRI volumetry, Magnetic Resonance Imaging, Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Nuclear magnetic resonance imaging, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson disease, Parkinson's disease, Severity of Illness Index, amygdala, dementia, hippocampus.
MESH :
- complications : Dementia, Parkinson Disease.
- diagnosis : Dementia, Parkinson Disease.
- pathology : Amygdala, Hippocampus.
- Aged, Aged, 80 and over, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.

Abstract

Parkinson's disease (PD) involves neuropathological changes in the limbic system that lead to neuronal loss and volumetric reductions of several nuclei. We investigated possible volumetric reductions of the amygdala and hippocampus associated to PD. We carried out magnetic resonance imaging (MRI) volumetric studies in 16 patients with PD and dementia (PDD), 16 patients with PD without dementia (PD), and 16 healthy subjects. The general analysis of variance (ANOVA) showed a significant group effect (for the amygdala, P = 0.01; for the hippocampus, P = 0.005). A post‐hoc test demonstrated that the differences were due to PDD and control group comparisons for the amygdala (P = 0.008) and for the hippocampus (P = 0.004). In nondemented PD subjects, we observed an 11% reduction in the amygdala and a 10% reduction in the hippocampus compared with that in controls. In summary, demented PD patients have clear amygdalar and hippocampal atrophy that remains statistically significant after controlling for global cerebral atrophy. Nondemented PD patients also showed a degree of volumetric reduction in these structures although the differences were not statistically significant. © 2005 Movement Disorder Society

Url:

https://api.istex.fr/document/511C6B90D55170230E261E0579B6A7EF3BD9D6F5/fulltext/pdf

DOI: 10.1002/mds.20371

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia</title>
<author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name>
</author>
<author><name sortKey="Ramirez Uiz, Blanca" sort="Ramirez Uiz, Blanca" uniqKey="Ramirez Uiz B" first="Blanca" last="Ramírez-Ruiz">Blanca Ramírez-Ruiz</name>
</author>
<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
</author>
<author><name sortKey="Summerfield, Christopher" sort="Summerfield, Christopher" uniqKey="Summerfield C" first="Christopher" last="Summerfield">Christopher Summerfield</name>
</author>
<author><name sortKey="Marti, Maria Ose" sort="Marti, Maria Ose" uniqKey="Marti M" first="María-José" last="Martí">María-José Martí</name>
</author>
<author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
</author>
<author><name sortKey="G Mez Ns N, Beatriz" sort="G Mez Ns N, Beatriz" uniqKey="G Mez Ns N B" first="Beatriz" last="G Mez-Ans N">Beatriz G Mez-Ans N</name>
</author>
<author><name sortKey="Mercader, Jose Ma" sort="Mercader, Jose Ma" uniqKey="Mercader J" first="José Ma." last="Mercader">José Ma. Mercader</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:511C6B90D55170230E261E0579B6A7EF3BD9D6F5</idno>
<date when="2005" year="2005">2005</date>
<idno type="doi">10.1002/mds.20371</idno>
<idno type="url">https://api.istex.fr/document/511C6B90D55170230E261E0579B6A7EF3BD9D6F5/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002876</idno>
<idno type="wicri:Area/Istex/Curation">002876</idno>
<idno type="wicri:Area/Istex/Checkpoint">002436</idno>
<idno type="wicri:doubleKey">0885-3185:2005:Junque C:amygdalar:and:hippocampal</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:15645532</idno>
<idno type="wicri:Area/PubMed/Corpus">003165</idno>
<idno type="wicri:Area/PubMed/Curation">003165</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003237</idno>
<idno type="wicri:Area/Ncbi/Merge">001136</idno>
<idno type="wicri:Area/Ncbi/Curation">001136</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001136</idno>
<idno type="wicri:doubleKey">0885-3185:2005:Junque C:amygdalar:and:hippocampal</idno>
<idno type="wicri:Area/Main/Merge">005113</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:05-0281339</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001E93</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000E28</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001F35</idno>
<idno type="wicri:doubleKey">0885-3185:2005:Junque C:amygdalar:and:hippocampal</idno>
<idno type="wicri:Area/Main/Merge">005413</idno>
<idno type="wicri:Area/Main/Curation">003A26</idno>
<idno type="wicri:Area/Main/Exploration">003A26</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia</title>
<author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramirez Uiz, Blanca" sort="Ramirez Uiz, Blanca" uniqKey="Ramirez Uiz B" first="Blanca" last="Ramírez-Ruiz">Blanca Ramírez-Ruiz</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Parkinson's disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Malalties del Sistema Nervios, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Summerfield, Christopher" sort="Summerfield, Christopher" uniqKey="Summerfield C" first="Christopher" last="Summerfield">Christopher Summerfield</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marti, Maria Ose" sort="Marti, Maria Ose" uniqKey="Marti M" first="María-José" last="Martí">María-José Martí</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Parkinson's disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Malalties del Sistema Nervios, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Parkinson's disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Malalties del Sistema Nervios, Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="G Mez Ns N, Beatriz" sort="G Mez Ns N, Beatriz" uniqKey="G Mez Ns N B" first="Beatriz" last="G Mez-Ans N">Beatriz G Mez-Ans N</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centre de Diagnòstic per la Imatge (CDI), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mercader, Jose Ma" sort="Mercader, Jose Ma" uniqKey="Mercader J" first="José Ma." last="Mercader">José Ma. Mercader</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centre de Diagnòstic per la Imatge (CDI), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2005-05">2005-05</date>
<biblScope unit="vol">20</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="540">540</biblScope>
<biblScope unit="page" to="544">544</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">511C6B90D55170230E261E0579B6A7EF3BD9D6F5</idno>
<idno type="DOI">10.1002/mds.20371</idno>
<idno type="ArticleID">MDS20371</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Amygdala</term>
<term>Amygdala (pathology)</term>
<term>Dementia</term>
<term>Dementia (complications)</term>
<term>Dementia (diagnosis)</term>
<term>Diagnostic and Statistical Manual of Mental Disorders</term>
<term>Female</term>
<term>Hippocampus</term>
<term>Hippocampus (pathology)</term>
<term>Humans</term>
<term>MRI volumetry</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Severity of Illness Index</term>
<term>amygdala</term>
<term>dementia</term>
<term>hippocampus</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dementia</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Amygdala</term>
<term>Hippocampus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Diagnostic and Statistical Manual of Mental Disorders</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Amygdale</term>
<term>Démence</term>
<term>Hippocampe</term>
<term>Imagerie RMN</term>
<term>Parkinson maladie</term>
<term>Système nerveux pathologie</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) involves neuropathological changes in the limbic system that lead to neuronal loss and volumetric reductions of several nuclei. We investigated possible volumetric reductions of the amygdala and hippocampus associated to PD. We carried out magnetic resonance imaging (MRI) volumetric studies in 16 patients with PD and dementia (PDD), 16 patients with PD without dementia (PD), and 16 healthy subjects. The general analysis of variance (ANOVA) showed a significant group effect (for the amygdala, P = 0.01; for the hippocampus, P = 0.005). A post‐hoc test demonstrated that the differences were due to PDD and control group comparisons for the amygdala (P = 0.008) and for the hippocampus (P = 0.004). In nondemented PD subjects, we observed an 11% reduction in the amygdala and a 10% reduction in the hippocampus compared with that in controls. In summary, demented PD patients have clear amygdalar and hippocampal atrophy that remains statistically significant after controlling for global cerebral atrophy. Nondemented PD patients also showed a degree of volumetric reduction in these structures although the differences were not statistically significant. © 2005 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
</region>
<settlement><li>Barcelone</li>
</settlement>
</list>
<tree><country name="Espagne"><region name="Catalogne"><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name>
</region>
<name sortKey="G Mez Ns N, Beatriz" sort="G Mez Ns N, Beatriz" uniqKey="G Mez Ns N B" first="Beatriz" last="G Mez-Ans N">Beatriz G Mez-Ans N</name>
<name sortKey="G Mez Ns N, Beatriz" sort="G Mez Ns N, Beatriz" uniqKey="G Mez Ns N B" first="Beatriz" last="G Mez-Ans N">Beatriz G Mez-Ans N</name>
<name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name>
<name sortKey="Marti, Maria Ose" sort="Marti, Maria Ose" uniqKey="Marti M" first="María-José" last="Martí">María-José Martí</name>
<name sortKey="Marti, Maria Ose" sort="Marti, Maria Ose" uniqKey="Marti M" first="María-José" last="Martí">María-José Martí</name>
<name sortKey="Mercader, Jose Ma" sort="Mercader, Jose Ma" uniqKey="Mercader J" first="José Ma." last="Mercader">José Ma. Mercader</name>
<name sortKey="Mercader, Jose Ma" sort="Mercader, Jose Ma" uniqKey="Mercader J" first="José Ma." last="Mercader">José Ma. Mercader</name>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<name sortKey="Ramirez Uiz, Blanca" sort="Ramirez Uiz, Blanca" uniqKey="Ramirez Uiz B" first="Blanca" last="Ramírez-Ruiz">Blanca Ramírez-Ruiz</name>
<name sortKey="Ramirez Uiz, Blanca" sort="Ramirez Uiz, Blanca" uniqKey="Ramirez Uiz B" first="Blanca" last="Ramírez-Ruiz">Blanca Ramírez-Ruiz</name>
<name sortKey="Summerfield, Christopher" sort="Summerfield, Christopher" uniqKey="Summerfield C" first="Christopher" last="Summerfield">Christopher Summerfield</name>
<name sortKey="Summerfield, Christopher" sort="Summerfield, Christopher" uniqKey="Summerfield C" first="Christopher" last="Summerfield">Christopher Summerfield</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003A26 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003A26 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:511C6B90D55170230E261E0579B6A7EF3BD9D6F5
   |texte=   Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia

Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.